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Guided by the outstanding writing talents of Brian K. Vaughan (Ultimate X-Men) and rising star artist Pia Guerra, this genre-busting and controversial series continues! After a mysterious plague devastates the global male population, Yorrick Brown is the last man left alive in a world of women. He has seen every man he knew die; his mother become de facto President; and his sister join a group of vicious killers. Now, seeking absolution for what he's been forced to do, he finds refuge with the church. But when the ring he was carrying for his fiancee is stolen, Yorick is suddenly struck down by the plague! Can his friends save him - and with him, the future of humanity? And what has become of his sister, Hero?